Who's involved in the MELD Project

Dr Sophie Adler-Wagstyl and Dr Konrad Adler-Wagstyl lead the MELD Project.

Sophie is an Academic Clinical doctor who completed a PhD on cortical morphometry and MR signal intensity analysis in paediatric epilepsy.

Konrad is a Sir Henry Wellcome Research Fellow at University College London, who his completed MB PhD on deep learning and cortical structure at the Univeristy of Cambridge.

Dr. Kirstie Whitaker from the Alan Turing Institute is our advisor on open, robust and generalisable science.

This project is co-supervised by Professor Torsten Baldeweg from the Great Ormond Street Institute of Child Health.

A number of centres world-wide are using the automated FCD detection code that is freely available to download. We are also collaborating with interested groups to build robust and generalisable tools. Please click here for a list of current collaborators.

Groups involved in the multi-centre collaboration

We are delighted that a number of different groups have joined our multi-centre collaboration.

Sophie and Konrad at OHBM
World map showing locations of collaborators.

Great Ormond Street Hospital (GOSH), UK

GOSH is a leading centre in paediatric epilepsy surgery in Europe. It has had a programme for surgery for treating epilepsy in children since 1992. We are working with clinicians such as Professor Helen Cross and Dr Roxana Gunny as well as researchers such as Dr David Carmichael and Dr Sara Lorio.

Cleveland Clinic, USA

We are working with Dr Irene Wang’s imaging research group at the Cleveland Clinic Epilepsy Center, Ohio, USA. The Cleveland Clinic Epilepsy Center is one of the largest epilepsy programmes in the world treating both adults and children.

National Hospital for Neurology and Neurosurgery, UK

The National Hospital for Neurology and Neurosurgery has the largest adult epilepsy surgery programme in the UK. The Epilepsy Imaging Group of the UCL Institute of Neurology has a long history of developing imaging techniques to improve surgical treatment for patients with epilepsy. We are working with Dr Gavin Winston and Prof John Duncan.

Greifswald Epilepsy Center, Germany

The Greifswald Epilepsy Center is part of the Neurological Department at the University Medicine of Greifswald with a long tradition since 1974. Presurgical diagnostic work-up in epilepsy patients has been performed since 1994. More than 2000 patients (adults and children) per year with epilepsy are treated in its outpatient clinic. We work with Dr. Felix von Podewils, Dr. Bernadette Gaida, Dr. Sönke Langner and Dr. Martin Domin.

Hospital De Mar, Spain

We work with the neuroradiologist Dr Sofia Gonzalez-Ortiz at the Hospital Del Mar in Barcelona, Spain. The mission of the Epilepsy Unit, of the Hospital de Mar, lead by Dr. Rodrigo R. Rocamora, is to be a national reference in the diagnosis and treatment of epilepsy throughout all ages of patients’ life. Investigators at our centre include Dr. Carmen Pérez and Dr. Ignacio Delgado.

Gaslini Institute, Genova, Italy

G. Gaslini Institute is a paediatric hospital based in Genova and is a national reference in the diagnosis and treatment of epilepsy and other neurodevelopmental diseases. There is a dedicated programme of research into epilepsy genetics and clinical management of the patients, including a programme for surgery.

Hospital Clinic of Barcelona, Spain

The Epilepsy Unit of the Hospital Clinic of Barcelona is a reference center of epilepsy surgery in Spain. From the Hospital Clínic we coordinate the Functional Unit of Epilepsy Surgery of Catalonia and we are also accredited by the Ministry of Health to evaluate patients referred from other autonomous communities that do not have this program. Since the creation of the Unit, we have evaluated more than 1,500 patients with refractory epilepsy and we have operated on more than 400 patients. One of our research lines are the utility of neuroimaging techniques, in helping to detect the epileptogenic focus. The head of the Epilepsy Unit is Dr Marr Carreño and the lead of the imaging group in Dr Nuria Bargalló.

Institute of Neurology at University Magna Graecia, Italy

The Institute of Neurology at University Magna Graecia in Catanzaro hosts a reference Epilepsy Center in Southern Italy. The research Unit, led by Prof. Antonio Gambardella and Prof. Angelo Labate, closely collaborates with the Neuroscience Research Center of University Magna Graecia and with the Institute of Molecular Bioimaging and Physiology of the National Research Council, both located in Catanzaro. In this setting, neurologists, neuropsychologists, biologists and neuroimaging experts collaborate to carry on multimodal research on epileptic syndromes, especially on Mild and refractory Temporal Lobe Epilepsy.

UNICAMP Epilepsy Surgery Programme and Laboratory of Neuroimaging, Brazil

The Epilepsy Imaging research team, coordinated by Prof. Fernando Cendes, is based on the Laboratory of Neuroimaging associate to the Department of Neurology of the University of Campinas (UNICAMP), Brazil. This lab provides conditions to evaluate and quantify structural and metabolic alterations of the CNS, using various techniques of MRI, for both imaging acquisition and postprocessing techniques of high complexity, and development of new tools and software for better evaluation of neuroimaging data. The Neuroimaging group at UNICAMP is inserted into one of the FAPESP Programs of Research and Innovation, The Brazilian Research Institute for Neuroscience and Neurotechnology (BRAINN http://cepid.fapesp.br/en/centro/11) with several projects funded, including undergraduate students, master’s, doctoral and postdoctoral studies.

The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

The Florey’s Epilepsy division is a world-leading centre for epilepsy research. The division has major groups at both the Florey’s Austin and Parkville campus. The group studies mechanisms that cause epilepsy from the level of cells to the function of the whole brain. We use technologies including advanced MRI and cutting edge cellular physiology techniques to allow us to understand genetic and acquired mechanisms that give rise to epilepsy.

Epilepsy and Neuropharmacology Research Group, Melbourne, Australia

The Research of the Epilepsy and Neuropharmacology Research Group is broad based, covering both basic and clinical studies relevant to epilepsy and related areas, including traumatic brain injury and dementing disorders.

Beijing Tiantan Hospital, China

The epilepsy center of Beijing Tiantan Hospital is one of the leading epilepsy centers in China, which is led by Prof Jianguo Zhang. Our research issues include neuroimaging, SEEG, epilepsy surgery and autoimmune epilepsy.

Children’s Meyer Hospital Anna Meyer, Florence, Italy

Children’s Meyer Hospital Anna Meyer in Florence is a reference pediatric hospital center in Italy. We work with Prof. Renzo Guerrini, head Director of the Neuroscience Department, whose research activities focus on neurophysiology, neuroimaging and neurogenetics of epilepsies, brain development and mental retardation. Prof. Guerrini’s group has made important contributions in characterizing the clinical phenotype and the genetic causes of various epilepsy or brain malformation syndromes and defining genotype-phenotype correlations.

The New York University Comprehensive Epilepsy Center, USA

The New York University Comprehensive Epilepsy Center is among the largest epilepsy treatment programs in the United States. Our research extends from fundamental epilepsy neurobiology to novel interventions for epilepsy treatment, and includes new drug development that includes cannabis-based and genetic therapies, development of imaging-based markers for epilepsy outcomes, the genetics of epilepsy, sudden unexplained death in epilepsy, treatments for neuroinflammation-induced epilepsy, tuberous sclerosis and epilepsy, autism and epilepsy, and many others.

Bristol Royal Hospital for Children, UK

Bristol Royal Hospital for Children is one of the four centres for the nationally commissioned Children’s Epilepsy Surgery Service (CESS) in England, providing surgical treatment for children with refractory partial epilepsy. The BCH program is led by Dr Jay Patel and Mr Mike Carter. Dr Marcus Likeman is the lead neuroradiologist for epilepsy imaging at BCH and for the adult epilepsy surgery program at Southmead Hospital Bristol.

University Hospital of Wales and Cardiff University, UK

The Epilepsy Unit at the University Hospital of Wales, Cardiff, UK under Dr Khalid Hamandi has worked closely with Cardiff University Brain Research Imaging Centre (CUBRIC) in developing a translational epilepsy research imaging programme using advanced MRI and MEG, this includes a service for the Wales epilepsy surgery programme, as well as ongoing brain imaging research in non-surgical epilepsies.

Geneva University Hospital

The EEG and Epilepsy Unit is specialized in the diagnosis and treatment of pharmacoresistant epilepsies. To achieve this goal we are currently dealing with cerebral imaging techniques to localise brain functions such as MRI, PET, SPECT, ESI, fMRI, electrocorticography. Because of a close collaboration with both universities (Geneva and Lausanne), the whole spectrum of modern diagnostic tools is available. Since beginning our work, more than 600 patients have been evaluated and most have also had operations; 40 to 45% of our patients were children and adolescents.

The Barrow Neurological Institute, USA

The Barrow Neurological Institute at Phoenix Children’s Hospital has a comprehensive and integrated neuroscience program spanning all “neuro” divisions and is affiliated with University of Arizona College of Medicine - Phoenix and Arizona State University. Our epilepsy center offers advanced technologies including 3T MRI, resting-state fMRI, SISCOM, sEEG and ECoG monitoring, laser ablation surgery, and responsive neurostimulation. Our research team includes neuroengineers, epileptologists, neuroradiologists, and neurosurgeon and is led by Stephen Foldes, PhD.

Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, Denmark

Neurobiology Research Unit (NRU) is located at Rigshospitalet, Copenhagen University Hospital, Denmark. The mission of NRU is to conduct translational neuroscience research on brain neurotransmission at an internationally competitive level with the aim to promote preventive, diagnostic and therapeutic advances. In the field of epilepsy, this includes several research initiatives using functional and structural imaging techniques, including investigation of the added value of 7T MRI. Danish epilepsy surgery is centralized at Rigshospitalet, and around 100 patients are evaluated here and at the Epilepsy Hospital Filadelfia annually. Epilepsy research at NRU is supervised by associate prof. Lars H. Pinborg.

Children’s National, Washington USA

The Children’s National Comprehensive Pediatric Epilepsy Program, directed by Professor William Gaillard is one of the leading multidisciplinary pediatric epilepsy programs in the USA. Their research uses advanced structural and functional imaging to examine the effects of epilepsy on brain structure and function. Their ultimate goal is to improve the outcomes and lives of children with epilepsy.

Bambino Gesù Children’s Hospital, Rome, Italy

The Bambino Gesù Children’s Hospital in Rome is one of the centers commissioned for epilepsy surgery in Italy and a referral center for pediatric epilepsy treatment and diagnosis. The diagnostic work-up encompasses EEG, SEEG, 3T MRI with dedicated protocols including DTI, fMRI resting state fMRI and advanced post-processing techniques for surgical planning. Since the beginning of our practice in 2010 more than 250 epilepsy cases, mainly paediatric, have been operated and more than 50 underwent SEEG.

If you are interested in getting involved in this collaboration please do not hesitate to contact us. In particular we are looking for interested epilepsy centres as well as research scientists, developers and database managers.